4744-25-6Relevant academic research and scientific papers
Cyclohexanedicarboxylic acid derivative with bridge ring and pharmaceutical composition and application thereof
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Paragraph 0081-0083; 0096-0097, (2021/11/10)
The invention discloses a cyclohexane dicarboxylic acid derivative with a bridged ring represented by general formula (I). The application of the stereoisomers and the pharmaceutically acceptable salts in the preparation of antitumor drugs has obvious inhibition effects on leukemia, liver cancer, lung cancer, gastric cancer and ovarian cancer. The compound disclosed by the invention has high anti-tumor activity, wide anti-tumor spectrum and low toxicity, and is suitable for preparing anti-cancer drugs.
CHEMICAL REPERCUSSIONS OF ORBITAL INTERACTIONS THROUGH BOND AND THROUGH SPACE. EFFECT OF REMOTE SUBSTITUENTS ON THE ADDITION OF NITRENES TO BICYCLIC OLEFINS
Aitken, R. Alan,Gosney, Ian,Farries, Hugh,Palmer, Michael H.,Simpson, Isobel,et. al.
, p. 1329 - 1346 (2007/10/02)
The reactivity of a series of bicyclic olefins with nitrenes is profoundly influenced by the nature of remote functional groups.There is a marked lack of reactivity for reactions with carboethoxynitrene as compared to phthalimidonitrene which is distinctly nucleophilic in character.An explanation for the reluctance to form aziridines is offered in terms of orbital interactions between the distant groups and the olefinic bond, making the latter remarkably electron deficient as evidenced by UV-photoelectron spectroscopy.Because of the complexity of the spectra, identification of the Ip associated with the reactive ?-centre was made by recourse to ab initio configuration interaction calculations for key members of the series.
