474404-92-7

Upstream product

• 114828-08-9 2,4,6-tri-O-benzyl-myo-inositol 
• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 18421-15-3 (±)-N-((1R,2R)-2-hydroxycyclohexyl)acetamide 
• 108-24-7 acetic anhydride 
• 1499-21-4 Diphenylphosphinic chloride 

Downstream Products

• 2831-74-5 D-myo-inositol-3-phosphate 
• 797038-10-9 1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol 
• 816426-24-1 2,4,6-tri-O-benzyl-D-myo-inositol-3-diphenylphosphate-1-O-thiocarbonic acid phenyl ester 
• 817165-57-4 2,4,6-tri-O-benzyl-D-myo-inositol-3-diphenylphosphate-1,5-O-dithiocarbonic acid diphenylester 
• 14980-89-3 D-myo-inositol-3-phosphate biscyclohexylamine salt 
• 797038-13-2 3-O-dibenzylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol 
• 797038-11-0 1,5-O-bis(t-butyldimethylsilyl)-3-O-dibenzylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol 
• 796883-91-5 Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester 
• 1173899-13-2 C₅₃H₅₁O₉P 
• 816426-23-0 5-O-acetate-2,4,6-tri-O-benzyl-D-myo-inositol-3-diphenylphosphate-1-O-thiocarbonic acid phenyl ester 
• 816426-25-2 5-O-acetate-2,4,6-tri-O-benzyl-D-myo-inositol-1-deoxy-3-diphenylphosphate 
• 817165-59-6 2,4,6-tri-O-benzyl-D-myo-inositol-3,5-dideoxy-1-diphenyl phosphate 
• 899827-46-4 2,4,6-tri-O-benzyl-5-O-tert-butyldimethylsilyl-D-myo-inositol-1-diphenylphosphate-1-O-thiocarbonic acid phenyl ester 
• 899827-48-6 2,4,6-tri-O-benzyl-5-O-tert-butyldimethylsilyl-D-myo-inositol-1-deoxy-3-dibenzyl phosphate 

Relevant academic research and scientific papers

Unified total syntheses of the inositol polyphosphates: D-I-3,5,6P 3, D-I-3,4,5P3, D-I-3,4,6P3, and D-I-3,4,5,6P4 via catalytic enantioselective and site-selective phosphorylation

Synthetic routes to various inositol polyphosphates have been discovered utilizing catalytic enantioselective and site-selective phosphorylation reactions. The syntheses described herein exploit a common intermediate to gain efficient access to eight unique inositol polyphosphates.

Outer-Sphere Control for Divergent Multicatalysis with Common Catalytic Moieties

We herein report two examples of one-pot, simultaneous reactions, mediated by multiple, orthogonal catalysts with the same catalytic motif. First, BINOL-derived chiral phosphoric acids (CPA) and phosphothreonine (pThr)-embedded peptides were found to be matched for two different steps in double reductions of bisquinolines. Next, two -methylhistidine (Pmh)-containing peptides catalyzed enantio- and chemoselective acylations and phosphorylations of multiple substrates in one pot. The selectivity exhibited by common reactive moieties is adjusted solely by the appended chiral scaffold through outer-sphere interactions.

Insights into the structural specificity of the cytotoxicity of 3-deoxyphosphatidylinositols

D-3-Deoxyphosphatidylinositol (D-3-deoxy-PI) derivatives have cytotoxic activity against various human cancer cell lines. These phosphatidylinositols have a potentially wide array of targets in the phosphatidylinositol-3-kinase (PI3K)/Akt signaling networ

Catalyst-dependent syntheses of phosphatidylinositol-5-phosphate-DiC8 and its enantiomer

Peptide-based catalysts have been applied to the enantioselective syntheses of the title compounds, with this being the first report of the synthesis of an ent-PI5P analogue. The key steps in the synthesis involve asymmetric phosphorylation catalysis. Add

Enantiodivergence in small-molecule catalysis of asymmetric phosphorylation: Concise total syntheses of the enantiomeric D-myo-inositol-1-phosphate and D-myo-inositol-3-phosphate

Peptide-based catalysts have been found that catalyze the enantiodivergent phosphorylation of a meso myo-inositol-derived triol (1). The sequential screening of random peptide libraries, followed by the evaluation of a focused library, led to the identifi