474432-85-4Relevant academic research and scientific papers
Hydroboration-Suzuki cross coupling of unsaturated amino acids; the synthesis of pyrimine derivatives
Collier, Philip N,Campbell, Andrew D,Patel, Ian,Taylor, Richard J.K
, p. 6117 - 6125 (2007/10/03)
Hydroboration of protected allylglycines with 9-BBN followed by Suzuki cross coupling of the resulting organoboranes proceeded smoothly giving a range of new bis-homophenylalanine and related derivatives in good yields (9 examples, 53-64%). One of the Suzuki coupling products has been elaborated to give the N-Cbz-protected natural product pyrimine. The hydroboration-Suzuki coupling of vinylglycine derivatives was also studied but was less efficient than with the allylglycine derivatives: the best results were obtained using disiamylborane·DMS as the hydroborating agent.
