474499-55-3

Basic information

• Product Name: {4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-phenyl}-acetic acid 3-hydroxy-2-hydroxymethyl-2-methyl-propyl ester
• CAS NO: 474499-55-3
• Molecular Weight: 551.535
• Mol File: 474499-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-phenyl}-acetic acid 3-hydroxy-2-hydroxymethyl-2-methyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-phenyl}-acetic acid 3-hydroxy-2-hydroxymethyl-2-methyl-propyl ester(474499-55-3)
• EPA Substance Registry System: {4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-phenyl}-acetic acid 3-hydroxy-2-hydroxymethyl-2-methyl-propyl ester(474499-55-3)

Safety Data

• Hazardous Substances Data: 474499-55-3(Hazardous Substances Data)

Upstream product

• 474499-53-1 (3,4-bis-difluoromethoxy-phenyl)-[4-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-ylmethyl)-phenyl]-methanol 
• 251359-05-4 1-(4-bromobenzyl)-4-methyl-2,6,7-trioxabiyclo[2.2.2]octane 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 127842-54-0 3,4-bis-(difluoromethoxy)-benzaldehyde 
• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 

Relevant articles and documents

Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.

Structure-activity relationship studies directed toward improving the potency and metabolic stability of CDP-840 (3) resulted in the discovery of L-791,943 (11n) as a potent (HWB TNF-alpha = 0.67 microM) and orally active phosphodiesterase type 4 (PDE4) inhibitor. This compound, which bears a stable bis-difluoromethoxy catechol and a pendant hexafluorocarbinol, exhibited a long half-life in rat and in squirrel monkey. It is well tolerated in ferret with an emetic threshold greater than 30 mg/kg (po) and was found to be active in the ovalbumin-induced bronchoconstriction model in guinea pig and in the ascaris-induced bronchoconstriction models in sheep and squirrel monkey.