474554-46-6

Upstream product

• 876384-14-4 6-aminomethyl-3,4-diethoxy-2-fluorobenzonitrile 
• 474554-45-5 4,5-diethoxy-3-fluorophthalonitrile 
• 756840-09-2 2-cyano-4,5-diethoxy-3-fluorobenzyl methanesulfonate 
• 756840-10-5 3,4-diethoxy-2-fluoro-6-(phthalimidemethyl)benzonitrile 

Downstream Products

• 474544-02-0 {3-tert-butyl-5-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-acetyl]-2-methoxy-phenylamino}-acetonitrile hydrobromide 
• 474544-32-6 (4-{3-tert-butyl-5-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-acetyl]-2-methoxyphenyl}piperazin-1-yl)-acetonitrile hydrobromide 
• 474623-38-6 1-{3-tert-butyl-4-methoxy-5-[4-(2-methoxyacetyl)piperazin-1-yl]phenyl}-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-ethanone hydrobromide 
• 474545-70-5 1-(3-tert-butyl-5-ethoxy-4-hydroxy-phenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-ethanone hydrobromide 
• 474549-79-6 1-(3-tert-butyl-5-ethoxy-4-methoxy-phenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-ethanone hydrobromide 
• 751475-53-3 atopaxar 
• 1180486-51-4 2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)-1-[3-ethoxy-5-(pentafluorosulfanyl)phenyl]ethanone hydrobromide 
• 1180486-50-3 N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]cyclopropanecarboxamide hydrochloride 
• 1180486-49-0 N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]cyclobutanecarboxamide hydrochloride 
• 1180486-34-3 N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide 
• 1180486-66-1 2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)-1-[3-ethoxy-5-(pentafluorosulfanyl)phenyl]propan-1-one trifluoroacetate 
• 1180486-55-8 1-[3-bromo-5-(pentafluorosulfanyl)phenyl]-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)ethanone trifluoroacetate 
• 1180486-31-0 N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]-N-methylacetamide trifluoroacetate 
• 474623-35-3 1-[3-(4-acetyl-piperazin-1-yl)-5-tert-butyl-4-methoxyphenyl]-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)ethanone hydrobromide 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES

One embodiment of the present invention is a pharmaceutical composition comprising at least one specific 2-iminopyrrolidine derivative and at least one other compound (B). Another embodiment of the present invention is a pharmaceutical composition compris

PROCESS FOR THE PRODUCTION OF ISOINDOLE DERIVATIVES

The present invention relates to a method for producing an isoindole derivative (compound (II)) with the following general formula (II): epImage id=""ia01"" he=""25"" wi=""59"" file=""imga0001.tif"" img-content=""chem"" img-format=""tif"" orientation=""p

PROCESSES FOR PRODUCING CYCLIC BENZAMIDINE DERIVATIVE

In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-

2-IMINOPYRROLIDINE DERIVATES

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101 - R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, -CH2-, etc.; Y2 represents a single bond, -CO-, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.