474670-20-7

Upstream product

• 339317-29-2 (R)-3-Dodecyloxy-tetradecanoic acid (2S,3R,4R,5S,6R)-2-allyloxy-6-benzyloxymethyl-5-hydroxy-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester 
• 339317-28-1 (R)-3-Dodecyloxy-tetradecanoic acid (2R,4aR,6S,7R,8R,8aS)-6-allyloxy-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 339316-65-3 (R)-3-Dodecyloxy-tetradecanoic acid 2-oxo-2-phenyl-ethyl ester 
• 338952-12-8 (R)-3-(dodecanoyloxy)tetradecanoic acid 
• 87357-65-1 (3R)-3-hydroxytetradecanoic acid phenacyl ester 
• 75618-27-8 lauryl triflate 
• 108549-23-1 Dibenzyl N,N-diisopropylphosphoramidite 
• 339317-30-5 (R)-3-Dodecyloxy-tetradecanoic acid (2S,3R,4R,5S,6R)-2-allyloxy-6-benzyloxymethyl-5-(bis-benzyloxy-phosphoryloxy)-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester 

Downstream Products

• 339317-32-7 (R)-3-Dodecyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-2-benzyloxymethyl-3-(bis-benzyloxy-phosphoryloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-5-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester 

Relevant academic research and scientific papers

Lipid A structures containing novel lipid moieties: Synthesis and adjuvant properties

Structurally well-defined immune stimulatory molecules are important components of new generation molecular vaccines. In this paper, the design and synthesis of two lipid A analogues containing an unnatural tri-lipid acyl group are described. In a totally synthetic liposomal vaccine system, these re-designed lipid A analogues demonstrate potent immune stimulatory properties including antigen specific T-cell activation.