474670-41-2

Upstream product

• 93711-81-0 (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 474670-28-5 (2S,5S,7S)-2-ethyl-2-methyl-7-mercapto-4-oxo-1,3-diazabicyclo[3.3.0]octane 
• 474670-26-3 (2R/S,5S,7R)-2-ethyl-2-methyl-7-mesyloxy-4-oxo-1,3-diazabicyclo[3.3.0]octane 
• 474670-27-4 (2S,5S,7S)-7-acetylthio-2-ethyl-2-methyl-4-oxo-1,3-diazabicyclo[3.3.0]octane 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of 1beta-methylcarbapenems having a 2, 2-disubstituted-1, 3-diazabicyclo[3.3.0]octan-4-one moiety and related compounds. Part III.

The synthesis of new series of 1beta-methylcarbapenems having a 2, 2-disubstituted-1, 3-diazabicyclo[3.3.0]octan- and -[4.3.0]nonan-4-one moiety is described.Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent of the bicyclic ring was investigated. A particular compound (16 f) bearing a hydroxymethyl group showed the most potent antibacterial activity and the compound (17 a) with a 1, 3-diazabicyclo[4.3.0]nonane moiety exhibited excellent stability against renal dehydropeptidase-I (DHP-I) to Meropenem.