474694-27-4Relevant academic research and scientific papers
Synthesis of 4-phenylpiperidines by tandem Wittig olefination-aza-Wittig rearrangement of 2-benzoylaziridines
Coldham, Iain,Collis, Alan J.,Mould, Roger J.,Rathmell, Richard E.
, p. 2739 - 2746 (2007/10/02)
A number of routes to 2-vinylaziridines are reported.N-Alkylation of a range of 2-benzoyl-3-alkylaziridines with tert-butyl bromoacetate followed by Wittig olefination gave directly a range of 4-phenylpiperidines.The intermediate 2-vinylaziridines rearran
Ring Expansion of Aziridines to Piperidines using the Aza-Wittig Rearrangement
Coldham, Iain,Collis, Alan J.,Mould, Roger J.,Rathmell, Richard E.
, p. 3557 - 3560 (2007/10/02)
A one-pot, two-step synthesis of unsaturated piperidines from 2-keto aziridines is reported.Treatment of a range of 2-keto aziridines with two equivalents of a phosphonium ylide generates intermediate vinyl aziridines which rearrange by a -sigmatropi
