47477-04-3

Upstream product

• 2730-81-6 (S)-7-Benzylidenamino-1,2,3,9-tetramethoxy-6,7-dihydro-5H-benzoheptalen-10-on 
• 73307-44-5 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one 
• 7469-68-3 (S)-7-((Ξ)-benzylidenamino)-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one 
• 477-27-0 colchiceine 
• 102491-72-5 (+/-)-N-(trifluoroacetyl)deacetylisocolchicine 
• 102491-70-3 (+/-)-N-(trifluoroacetyl)deacetylcolchiceine 
• 209810-38-8 N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide 
• 64-86-8 colchicine 
• 102491-74-7 (+/-)-N-deacetylisocolchicine 
• 186581-53-3 diazomethane 
• 3482-37-9 trimethylcolchicinic acid 

Relevant academic research and scientific papers

Semisyntheses, X-Ray Crystal Structures and Tubulin-Binding Properties of 7-Oxodeacetamidocolchicine and 7-Oxodeacetamidoisocolchicine

Commercially available (-)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3).The X-ray structures and tubulin-binding properties of these title ketones are described.