474801-73-5

Upstream product

• 474801-41-7 (2S,4S,5S,6R)-5-Acetylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-[(S)-cyclohexylmethoxy-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-2-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 474801-58-6 (4S,5R,6R)-5-Acetylamino-4-azido-6-((1S,2R)-2,3-diacetoxy-1-cyclohexylmethoxy-propyl)-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester 
• 474801-19-9 di(cyclohexylmethyl)sulfate 
• 959283-67-1 sulfurous acid, di(cyclohexylmethyl) ester 
• 100-49-2 cyclohexylmethyl alcohol 
• 105252-44-6 Methyl-5-(acetylamino)-4-O-(tert-butyldimethylsilyl)-3,5-dideoxy-8,9-O-isopropyliden-β-D-glycero-D-galacto-2-nonulopyranosidonsaeure-methylester 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 

Relevant academic research and scientific papers

Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir

A series of 7-alkyl ether derivatives related to zanamivir were synthesized using direct alkylation of the C-7 alcohol of sialic acid. Alkyl ether moiety of less than 12 carbons in length showed low nanomolar inhibitory activity against influenza A virus sialidase. Furthermore, their moiety improved influenza A virus plaque reduction activity compared to zanamivir. However, removal of the 8,9-diol of the 7-O-alkyl derivatives resulted in loss of antiviral potency. This result suggests that 8,9-diol must play an important role in binding with both influenza A and B virus sialidases.