474844-23-0Relevant articles and documents
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B
Andersen, Henrik Sune,Olsen, Ole H.,Iversen, Lars F.,S?rensen, Anette L. P.,Mortensen, Steen B.,Christensen, Michael S.,Branner, Sven,Hansen, Thomas K.,Lau, Jesper F.,Jeppesen, Lone,Moran, Edmond J.,Su, Jing,Bakir, Farid,Judge, Luke,Shahbaz, Manou,Collins, Tassie,Vo, Todd,Newman, Michael J.,Ripka, William C.,M?ller, Niels Peter H.
, p. 4443 - 4459 (2007/10/03)
Reversible phosphorylation and dephosphorylation of key proteins on tyrosine residues are important parts of intracellular signaling triggered by hormones and other agents. Recent knock-out studies in mice have identified PTP1B as a potential target for t
