47488-71-1

Upstream product

• 2679-26-7 2-Methylpapaverinium iodide 
• 58-74-2 Papaverine 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 4673-06-7 6,7-dimethoxy-2-methyl-1-veratrylidene-1,2-dihydro-isoquinoline 

Downstream Products

• 1699-51-0 laudanosine 
• 494-99-5 1,2-dimethoxy-4-methylbenzene 
• 10548-84-2 ethoxymethyl-4 dimethoxy-1,2 benzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5531-95-3 N-methylpavine 
• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 74046-23-4 6,7-dimethoxy-2-methylisoquinolinium chloride 
• 5531-95-3 N-methylpavine 

Relevant academic research and scientific papers

Evidence for a Radical Chain Mechanism for the Knabe Reaction of 1,2-Dihydro-2-methylpapaverine

A free radical chain mechanism is proposed for the Knabe reaction and the accompanying elimination reaction on account of their nonintegral reaction order and of successful inhibition experiments. 3,4-Dimethoxybenzyl radicals are the chain carrying species.Battersby's synthesis of N-methylpavine (19) from 1,2-dihydro-2-methylpapaverine (9) is dependent on the presence of formic acid as radical chain inhibitor.In the presence of inhibitors 1-benzyl-1,4-dihydro-2-methylisoquinolinium ions like 10 are persistent species whose chemistry can now be investigated.