474915-79-2

Upstream product

• 474915-77-0 (2R,3S)-2,3-O-isopropylidene-2-[(S)-1-triisopropylsiloxy-3-phenyl-2-propynyl]-pentanoic acid 
• 474915-75-8 (2R,3S)-methyl 2,3-O-isopropylidene-2-[(S)-1-triisopropylsiloxy-3-phenyl-2-propynyl]pentanoate 
• 474915-71-4 (2S,3S)-methyl 2,3-O-isopropylidene-2-[(S)-1-hydroxy-3-phenyl-2-propynyl]pentanoate 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 

Downstream Products

• 474915-81-6 (4S,5R,9S)-8-(Z)-benzylidene-4-ethyl-2,2-dimethyl-9-triisopropylsiloxy-1,3-dioxa-7-azaspiro[4.4]nonan-6-one 
• 474915-86-1 (3S,4S)-5-(Z)-benzylidene-3-hydroxy-3-propionyl-4-triisopropylsiloxypyrrolidin-2-one 
• 474915-83-8 (3R,4S)-5-(Z)-benzylidene-3-hydroxy-3-((S)-1-hydroxypropyl)-4-triisopropylsiloxypyrrolidin-2-one 
• 474915-88-3 (3S,4S)-5-(Z)-benzylidene-3-hydroxy-3-(3-hydroxy-2-methylnona-4,6-dienoyl)-4-triisopropylsiloxypyrrolidin-2-one 
• 474915-94-1 (5S,8R,9R)-8-benzyl-2-(E,E-hexa-1,3-dienyl)-8-hydroxy-3-methyl-9-triisopropylsiloxy-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione 

Relevant academic research and scientific papers

Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor

The asymmetric total synthesis of (-)-azaspirene, an angiogenesis inhibitor, has been accomplished, establishing its absolute stereochemistry. The key steps are a MgBr2·OEt2-mediated, diastereoselective Mukaiyama aldol reaction, a NaH-promoted, intramolecular cyclization of an alkynylamide, and the aldol reaction of a ketone containing functionalized γ-lactam moiety without protection of tert-alcohol and amide functionalities. Copyright