474917-82-3

Upstream product

• 474917-81-2 2-{4-[2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-butoxy}-6-hydroxy-benzoic acid methyl ester 
• 2150-45-0 methyl 2,6-dihydroxybenzoate 
• 436864-52-7 2-(4-tert-butoxycarbonylaminobutoxy)-6-hydroxybenzoic acid methyl ester 
• 436864-53-8 methyl 2-(4-aminobutoxy)-6-hydroxybenzoate 

Downstream Products

• 474917-90-3 methyl 2-[4-({N-(tert-butoxycarbonyl)-4-[(3-ethoxy-1-ethyl-3-oxopropyl)amino]-L-phenylalanyl}amino)butoxy]-6-hydroxybenzoate 

Relevant academic research and scientific papers

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Monoacid-based PTP1B inhibitors with improved physiochemical properties have been investigated. A (2-hydroxy-phenoxy) acetic acid-based phosphotyrosyl mimetic has been linked with an optimized second arylphosphate binding site ligand to produce compound 20 with low micromolar potency against PTP1B, good selectivity over TCPTP (20-fold) and high cell permeability in the Caco-2 system.