474971-00-1

Basic information

• Product Name: (allyloxycarbonylmethyl-{2-[allyloxycarbonylmethyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-amino)-acetic acid allyl ester
• Synonyms: (allyloxycarbonylmethyl-{2-[allyloxycarbonylmethyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-amino)-acetic acid allyl ester
• CAS NO: 474971-00-1
• Molecular Weight: 497.589
• Mol File: 474971-00-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (allyloxycarbonylmethyl-{2-[allyloxycarbonylmethyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-amino)-acetic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (allyloxycarbonylmethyl-{2-[allyloxycarbonylmethyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-amino)-acetic acid allyl ester(474971-00-1)
• EPA Substance Registry System: (allyloxycarbonylmethyl-{2-[allyloxycarbonylmethyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-amino)-acetic acid allyl ester(474971-00-1)

Safety Data

• Hazardous Substances Data: 474971-00-1(Hazardous Substances Data)

Upstream product

• 40630-84-0 allyl bromoacetate 
• 193206-49-4 [2-(2-amino-ethylamino)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis and evaluation of Taxol-folic acid conjugates as targeted antineoplastics

A series of Taxol derivatives tethered at C2′ and C-7 to glutamate and folate have been synthesized for evaluation as prodrugs which release Taxol via hydrolytic lability of their α-alkoxy and α-amino esters. The half-time for hydrolysis of these materials was determined in pH 7 and pH 5 buffer. The in vitro cytotoxicity has been assessed in cell culture against A-549 lung cancer, MCF-7 breast cancer, and HT-29 colon cancer. Selected agents were further screened for folate binding and competitive binding with free folic acid. One agent (54), further evaluated in animal studies was found to increase the lifespan in mice, but was less effective than Taxol itself.