474974-07-7Relevant academic research and scientific papers
Stereoselective synthesis of (Z)-fluoroalkenes directed to peptide isosteres: Copper mediated reaction of trialkylaluminum with 4,4-difluoro-5-hydroxyallylic alcohol derivatives
Nakamura, Yuko,Okada, Midori,Sato, Azusa,Horikawa, Hiroaki,Koura, Minoru,Saito, Akio,Taguchi, Takeo
, p. 5741 - 5753 (2005)
Copper mediated alkyl-transfer reaction of trialkylaluminum (R 3Al) with (E)-4,4-difluoro-5-hydroxyallylic alcohol derivative smoothly proceeded to give the corresponding 2-alkylated 4-fluoro-5- hydroxyhomoallylic alcohol derivative with comple
Preparation of δ-fluorinated homoallylic alcohol derivatives via regioselective hydride reduction of allylic alcohol derivatives
Nakamura, Yuko,Okada, Midori,Horikawa, Hiroaki,Taguchi, Takeo
, p. 143 - 148 (2007/10/03)
δ-Fluoro and δ,δ-difluorohomoallylic alcohol derivatives can be efficiently prepared by LiAlH4 reduction of the δ,δ-difluoroallylic alcohols and the γ-chlorodifluoromethylallylic alcohols, respectively, through regioselective SN2′ reaction, in
