475-25-2

Basic information

• Product Name: HEMATEIN
• Synonyms: TIMTEC-BB SBB006464;2-d)pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz(b)indeno(;2-d]pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz[b]indeno[;3,4,6a,10-tetrahydroxy-6a,7-dihydrobenz(b)indeno(1,2-d)pyran-9(6h)-one;abcolhematinelg;hematine;LABOTEST-BB LT00441274;HYDROXYBRASILEIN
• CAS NO: 475-25-2
• Molecular Formula: C₁₆H₁₂O₆
• Molecular Weight: 300.26
• EINECS: 207-492-8
• Product Categories: G-H-I;Stains and Dyes;Stains&Dyes, A to
• Mol File: 475-25-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 180 °C
• Boiling Point: 361.5°C (rough estimate)
• Flash Point: 289 °C
• Appearance: Dark brown/Crystalline Powder
• Density: 1.2766 (rough estimate)
• Vapor Pressure: 1.32E-17mmHg at 25°C
• Refractive Index: 1.4600 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Methanol (Slightly)
• PKA: 8.02±0.40(Predicted)
• Water Solubility: 0.6g/L(20 oC)
• Merck: 13,4651
• BRN: 93039
• CAS DataBase Reference: HEMATEIN(CAS DataBase Reference)
• NIST Chemistry Reference: HEMATEIN(475-25-2)
• EPA Substance Registry System: HEMATEIN(475-25-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: DE3120000
• F: 8-10-23
• Hazardous Substances Data: 475-25-2(Hazardous Substances Data)

Usage

Chemical Properties

dark brown crystalline powder

Uses

Different sources of media describe the Uses of 475-25-2 differently. You can refer to the following data:
1. CK2 inhibitor, antineoplastic, TNFa inhibitor, antiinflammatory
2. As an indicator like hematoxylin; for staining animal tissue, particularly cell nuclei.
3. Hematein is a stain for the cell nuclei of animal tissue. Also suggested to possess use as a stain for myelin sheaths and nerve fibers. An oxidized version of hematoxylin. Color index: 75290. Dyes and metabolites.

Definition

ChEBI: An organic heterotetracyclic compound that is -6a,7-dihydrobenzo[b]indeno[1,2-d]pyran-9-one carrying four hydroxy substituents at positions 3, 4, 6a and 10.

InChI:InChI=1/C16H12O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-3,17,20-21H,4-6H2/t16-/m1/s1

Synthetic route

haematoxylin → haematein (475-25-2)

Conditions	Yield
With ammonia Behandeln mit Essigsaeure;
With ammonia at 130℃;
With iodine; mercury(II) oxide

hematoxylin (17647-60-8) → hydroxyhematoxylin + haematein (475-25-2)

Conditions	Yield
With water Mechanism; Electrolysis;

haematein (475-25-2) → hydroxyhematoxylin

Conditions	Yield
With water Electrolysis;	7%

dimethyl sulfate (77-78-1) + haematein (475-25-2) + KOH-solution → haematein-tetramethyl ether + pentamethyl-dihydrohaemateinol

Conditions	Yield

yttrium(III) chloride (10361-92-9) + haematein (475-25-2) → Y(C16H8O6)2(5-)*4H(1+)

Conditions	Yield
In water

lead(II) nitrate + haematein (475-25-2) → 2Pb(2+)*C16H8O6(4-)*4H2O={Pb2(C16H8O6)}*4H2O

Conditions	Yield
In ammonia addn. of aq. Pb(NO3)2-soln. to aq. ammoniacal soln. of C16H12O6;; pptn.;

silver nitrate + haematein (475-25-2) → silver(I) hematein complex

Conditions	Yield
In ethanol

lead acetate (301-04-2) + haematein (475-25-2) → hematein lead(II) complex

Conditions	Yield
In ethanol

gadolinium(III) chloride + haematein (475-25-2) → hematein gadolinium(III) complex

Conditions	Yield
In ethanol

Upstream product

• 17647-60-8 hematoxylin 

Relevant articles and documents

-

-