475062-22-7

Upstream product

• 475062-21-6 2-(3-hydroxy-piperidin-1-yl)-3-{2-[2-(4-methoxy-benzyl)-2H-tetrazol-5-yl]-vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylic acid (4-tert-butyl-thiazol-2-yl)-amide 
• 712267-69-1 2-hydroxy-3-{2-[2-(4-methoxy-benzyl)-2H-tetrazol-5-yl]-vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylic acid (4-tert-butyl-thiazol-2-yl)-amide 
• 475062-18-1 N-(4-tert-butyl-1,3-thiazol-2-yl)-3-formyl-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide 
• 91660-72-9 ethyl 2-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]acetate 

Relevant academic research and scientific papers

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Exchange of the ethylene tether in a series of pyridopyrimidine-based MexAB-OprM specific efflux pump inhibitors to an amide bond stabilized the olefin of the acrylic acid moiety, preventing facile photoisomerization to the Z-isomer. Furthermore, the activity was drastically improved in the amide tether variants, providing extremely potent acrylic acid and vinyl tetrazole analogues.