475091-36-2Relevant academic research and scientific papers
4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action
Vergelli, Claudia,Giovannoni, Maria Paola,Pieretti, Stefano,Giannuario, Amalia Di,Piaz, Vittorio Dal,Biagini, Pierfrancesco,Biancalani, Claudio,Graziano, Alessia,Cesari, Nicoletta
, p. 5563 - 5575 (2007)
A series of 4-amino-5-vinyl-3(2H)-pyridazinones and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Several of the novel compounds showed ED50 values in the range 6-20 mg/kg/s
Isoxazolo[3,4-d]pyridazinones and analogues as Leishmania mexicana PDE inhibitors
Piaz, Vittorio Dal,Rascon, A.,Dubra, M. E.,Giovannoni, M. P.,Vergelli, C.,Castellana, M. C.
, p. 89 - 96 (2007/10/03)
A series of isoxazolopyridazinones and analogues has been prepared and evaluated as Leishmania mexicana phosphodiesterase (PDE) inhibitors. Some of the synthesized compounds showed a moderate PDE inhibitory activity at 100 μM and preliminary structure-act
