475101-82-7Relevant articles and documents
A class of DL-tryptophan compounds, preparation method and applications thereof
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, (2020/06/17)
The invention provides a DL-tryptophan compound represented by a general formula I or a pharmaceutically acceptable salt thereof, a preparation method and applications thereof, especially applicationsin preparation of RANKL inhibitors. According to the DL-tryptophan compound or the pharmaceutically acceptable salt thereof, an OPG-RANKL-RANK signal system can be intervened by inhibiting the interaction of RANKL-RANK, and the activity of RANKL in osteoclast precursor cells is regulated and controlled, so that formation of osteoclasts is inhibited, and bone resorption is reduced; and the DL-tryptophan compound or the pharmaceutically acceptable salt thereof is expected to play a role in preventing and treating bone metabolic diseases, and brings good news to bone metabolic disease patients.
N-1 and C-2 substituted tryptophans as potential inhibitors of sickel cell hemoglobin gelation
Prasitpan,Patel,De Croos,Stockwell,Manavalan,Kar,Johnson,Currie
, p. 335 - 341 (2007/10/02)
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