475102-11-5

Usage

Uses

Used in Organic Synthesis:
4-Chloro-N-(Boc)-indole-2-boronic acid is used as a building block for the synthesis of complex organic molecules. Its boronic acid functionality allows it to form stable covalent bonds with diols, facilitating the construction of diverse molecular structures.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Chloro-N-(Boc)-indole-2-boronic acid is used as a key intermediate for the development of biologically active molecules. The presence of the indole ring, a common structural motif in many bioactive compounds, combined with the reactivity of the boronic acid group, makes 4-Chloro-N-(Boc)-indole-2-boronic acid a promising candidate for the synthesis of novel pharmaceutical agents.
Used in Drug Design and Development:
4-Chloro-N-(Boc)-indole-2-boronic acid is employed as a versatile building block in drug design and development. Its unique structural features and reactivity enable the creation of new drug candidates with potential therapeutic applications, including the treatment of various diseases and disorders.

InChI:InChI=1/C13H15BClNO4/c1-13(2,3)20-12(17)16-10-6-4-5-9(15)8(10)7-11(16)14(18)19/h4-7,18-19H,1-3H3

Upstream product

• 129822-46-4 tert-butyl 4-chloro-1H-indole-1-carboxylate 
• 25235-85-2 4-chloro-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5419-55-6 Triisopropyl borate 

Downstream Products

• 1443151-93-6 tert-butyl 4-chloro-2-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,2-triazin-2-yl)-1H-indole-1-carboxylate 
• 1443151-42-5 4-(4-chloro-1H-indol-2-yl)-N-[2-(4-fluorophenyl)ethyl]-6-methoxy-1,3,5-triazin-2-amine 
• 1004558-24-0 4-chloro-2-(4-chloro-3-cyclohexylsulfamoyl-phenyl)-indole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

1,3,5-TRIAZINE-2-AMINE DERIVATIVES, PREPARATION THEREOF AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF

The present invention relates to compounds corresponding to formula (I) in which: - R1 represents a substituted phenyl; - R2 represents: - a substituted phenyl; - a heteroaromatic group, the said group being unsubstituted or substituted one or more times; - R3 represents a group Alk; - R4 represents a hydrogen atom or a (C1-C4)alkyl; - R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; - or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; - R6 represents a group -COOAlk, a group -CONH2 or a group -NHSO2 Alk; - Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use

2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

The present invention is directed to 2-phenyl-indole compounds (A), their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not li

A non-cryogenic method for the preparation of 2-(indolyl) borates, silanes, and silanols

2-Indolyl borates are prepared via addition of LDA to a mixture of N-Bo-indole and triisopropyl borate at 0-5 °C. Following acidic hydrolysis, the boronic acids are isolated by crystallization in good to excellent yield (73-99%). The method is quite general, tolerating a wide range of functional groups, and also provides access to 2-silyl derivatives (80-91%).