475105-35-2

Basic information

• Product Name: (S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE
• Synonyms: (S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE;(S)-2-AMINOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-TERT-BUTYL-2-(AMINOMETHYL)PIPERIDINE-1-CARBOXYLATE;(S)-1-N-Boc-2-(aminomethyl)piperidine;REF DUPL: (S)-2-Aminomethyl-1-N-Boc-piperidine;(2S)-2-(Aminomethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;(S)-2-(Aminomethyl)-1-Boc-piperidine;tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate
• CAS NO: 475105-35-2
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3
• Mol File: 475105-35-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 299.4 °C at 760 mmHg
• Flash Point: 134.9 °C
• Appearance: /
• Density: 1.023
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.481
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.32±0.29(Predicted)
• CAS DataBase Reference: (S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE(475105-35-2)
• EPA Substance Registry System: (S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE(475105-35-2)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61
• Hazardous Substances Data: 475105-35-2(Hazardous Substances Data)

Usage

Description

(S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE is an organic compound characterized by its six-membered heterocyclic ring structure with a nitrogen atom, known as piperidine. It features a tert-butoxycarbonyl (Boc) protecting group attached to the nitrogen atom, which is a common practice in organic synthesis to temporarily mask reactive sites. This Boc group enables selective reactions at other functional groups without interference from the nitrogen atom, making (S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE a versatile intermediate in the synthesis of pharmaceuticals and research chemicals.

Uses

Used in Pharmaceutical Synthesis:
(S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE is used as a building block for the production of various drugs, particularly in the development of new pharmaceuticals and biologically active compounds. Its unique structure and the presence of the Boc protecting group make it a valuable component in the synthesis of complex organic molecules with potential therapeutic applications.
Used in Research Chemicals:
In the field of research, (S)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE serves as a key intermediate for the synthesis of a wide range of research chemicals. Its ability to participate in selective reactions allows scientists to explore new chemical pathways and develop novel compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-4-6-9(13)8-12/h9H,4-8,12H2,1-3H3/t9-/m0/s1

Upstream product

• 475105-34-1 (S)-2-[(2,2,2-trifluoro-ethanoylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester 

Downstream Products

• 1609341-89-0 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethyl-N-[(2S)-piperidin-2-ylmethyl]imidazo[1,2-a]pyridine-3-carboxamide 

Relevant articles and documents

N-ARYL ACETYL CYCLIC AMINE DERIVATIVES AS OREXIN ANTAGONISTS

The present invention provides N-aryl acetyl cyclic amine derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors. In particular, theses compounds are of potential use in the treatment of obesity, includin