475110-08-8Relevant academic research and scientific papers
Synthesis of novel chiral macrolides and their antifungal activity
Gao, Ming Zhang,Gao, Jian,Xu, Zun Le,Zingaro, Ralph A.
, p. 5001 - 5003 (2002)
Nineteen chiral macrocyclic diamide-diester ligands were synthesized using a three step reaction. The synthesis utilized the condensation of dicarbonyl dichlorides with chiral 2-aminoethanol derivatives. The reaction was catalyzed in a dual catalyst system. Some of the compounds were found to display antifungal activity.
Synthesis and structures of new chiral diamide-ester macrocycles
Gao, Ming Zhang,Reibenspies, Joseph H.,Wang, Bo,Xu, Zun Le,Zingaro, Ralph A.
, p. 899 - 908 (2007/10/03)
A series of new hetero-macrocyclic diamide-ester compounds (4a - 4z, 6a - 6b) were synthesized using 4-(dimethylamino)pyridine as catalyst and characterization by infrared spectra, nuclear magnetic resonance spectra, mass spectra and elemental analyses. The structures of 4e and meso 4b were determined by X-ray crystallography. The association constants of the compounds with various metal ions were determined by UV-visible spectroscopic titration, and showed a selective recognition for certain metal ions.
