475148-08-4

Upstream product

• 107-18-6 allyl alcohol 
• 184377-91-1 (2R,4R)-2,4-dibenzyl-3-hydroxypentanedioic acid 

Downstream Products

• 475148-09-5 (2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester 
• 475148-15-3 (2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester pentafluorophenyl ester 
• 475148-17-5 (2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid (R)-2-amino-1-((R)-1-amino-2-phenyl-ethyl)-3-phenyl-propyl ester pentafluorophenyl ester 
• 475148-14-2 (2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid mono-[(R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl] ester 
• 727985-24-2 (2R,4R)-4-((1R,3R)-3-Amino-1-benzyl-2-hydroxy-4-phenyl-butylcarbamoyl)-2-benzyl-3-hydroxy-5-phenyl-pentanoic acid allyl ester 
• 475148-16-4 (3R,6R,8R)-2-((R)-1-Amino-2-phenyl-ethyl)-3,6,8-tribenzyl-7-hydroxy-[1,4]oxazonane-5,9-dione 

Relevant academic research and scientific papers

Synthesis of a tetrabenzyl-substituted 10-membered cyclic diamide

A conformationally constrained 10-membered cyclic diamide was designed and synthesized. Conformational analysis suggested that the 9-membered ring formation was preferred to the direct formation of 10-membered ring. On the basis of the prediction, lactonization of 9-membered lactone, followed by intramolecular ester-amide transformation afforded the desired 10-membered cyclic diamide.