475174-92-6

Upstream product

• 475174-71-1 7-bromo-2-ethyl-3-nitropyrazolo[1,5-a]pyridine 
• 475174-68-6 7-bromo-2-ethylpyrazolo[1,5-a]pyridine 
• 475174-64-2 1-(but-1-yn-1-yl)pyridine 
• 685886-45-7 7-bromo-2-ethylpyrazolo[1,5-a]pyridine-3-amine 
• 475174-67-5 N-amino-2-(1-butynyl)pyridinium mesitylenesulfonate 
• 475174-65-3 2-ethylpyrazolo[1,5-a]pyridine 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 475171-81-4 N-(cyclopropylmethyl)-2-ethyl-7-(2-methoxy-4,6-dimethylphenyl)-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: Potent and orally active antagonists of corticotropin-releasing factor 1 receptor

Design, synthesis, and structure-activity relationships of a series of 3-dialkylamino-7-phenyl pyrazolo[1,5-a]pyridines (I) as selective antagonists of the corticotropin-releasing factor 1 (CRF1) receptor are described. The most prominent compound to emerge from this work, 46 (E2508), exhibits potent in vitro activity, excellent drug-like properties, and robust oral efficacy in animal models of stress-related disorders. It has advanced into clinical trials.