475197-89-8Relevant academic research and scientific papers
Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone
Schnell, Simon D.,Linden, Anthony,Gademann, Karl
, p. 1144 - 1147 (2019/05/16)
A concise route toward two advanced fragments in the context of the total synthesis of the unique natural product azamerone is reported. Key synthetic features include the enantioselective synthesis of an epoxysilane and its Lewis-acid-induced cyclization and the installation of the pyridazine ring via a formylation/condensation sequence. This route provides strategic insights into the chemistry of phthalazinediols, facilitating synthetic approaches toward this class of natural products.
Enantioselective synthesis of both enantiomers of γ-ionone, γ-damascone, karahana lactone and karahana ether
Beszant, Stephen,Giannini, Elios,Zanoni, Giuseppe,Vidari, Giovanni
, p. 1245 - 1255 (2007/10/03)
A straightforward enantioselective synthesis of both enantiomers of the title compounds is described starting from enantiopure methyl (2S,6R)- or (2R,6S)-cis-2-hydroxy-γ-cyclogeraniate. These versatile building blocks are obtained by biomimetic cyclizatio
