475207-44-4Relevant academic research and scientific papers
Syntheses of chiral homoazacalix[4]arenes incorporating amino acid residues: Molecular recognition for racemic quaternary ammonium ions
Ito, Kazuaki,Noike, Motoyoshi,Kida, Atsushi,Ohba, Yoshihiro
, p. 7519 - 7522 (2002)
Chiral calixarene analogues incorporating amino acid residues into the macrocyclic rings were prepared from the cyclization reactions of bis(chloromethyl)phenol-formaldehyde tetramer with amino acid methyl ester in moderate yields. The macrocycles form a chiral concavity, which is induced by the chiral transmission from the point chirality of the amino acid residues to the phenol-formaldehyde tetramer unit. The macrocycles have the cavity π-basic enough to include the quaternary ammonium ion due to the cation-π interaction and can serve as a shift reagent for racemic ammonium ions during 1H NMR analysis.
