47522-06-5

Usage

Uses

Used in Pharmaceutical Applications:
L-Valine, N-(triphenylmethyl)is used as a pharmaceutical compound for its potential therapeutic uses. The unique chemical properties and interactions with biological systems may offer new avenues for drug development and treatment of various conditions.
Used in Biochemical Research:
L-Valine, N-(triphenylmethyl)is used as a research tool in biochemical studies to explore its unique properties and interactions with biological systems. L-Valine, N-(triphenylmethyl)may provide insights into the role of amino acids in protein synthesis and muscle repair, as well as the effects of chemical modifications on their functions.
Used in Drug Delivery Systems:
L-Valine, N-(triphenylmethyl)may be employed in the development of drug delivery systems, leveraging its unique chemical properties to improve the delivery, bioavailability, and therapeutic outcomes of various pharmaceutical agents.
Used in Nutritional Supplements:
As a derivative of the essential amino acid L-valine, L-Valine, N-(triphenylmethyl)may be used in nutritional supplements to support protein synthesis and muscle repair, particularly for individuals with specific dietary needs or those seeking to enhance their athletic performance.

Upstream product

• 72-18-4 L-valine 
• 76-83-5 trityl chloride 
• 7480-78-6 O-(Trimethylsilyl)valine 

Downstream Products

• 54244-58-5 Valyl-tyrosine Methyl Ester 
• 115731-97-0 Trt-Val-ODpm 
• 109745-84-8 (S)-4-Methyl-2-[(S)-3-methyl-2-(trityl-amino)-butyrylamino]-pentanoic acid methyl ester 
• 89028-29-5 N-Trityl-L-valyl-S-trityl-L-cysteinyl-L-alanyl-L-leucin-methylester 
• 100841-20-1 (S)-(+)-3-Methyl-2-triphenylmethylamino-1-butanol 
• 151011-78-8 N-trityl-L-valine 2-mercaptopyridine ester 
• 220081-19-6 (S)-5-Methyl-3-oxo-4-(trityl-amino)-hexanoic acid allyl ester 
• 100841-29-0 N-Trityl-L-phenylalanyl-D-valinol 
• 100841-27-8 Toluene-4-sulfonic acid; compound with (R)-2-amino-3-methyl-butan-1-ol 
• 108722-10-7 1-benzyl-N^α-benzyloxycarbonyl-L-histidyl=>L-valyl=>L-tyrosine-methyl ester 
• 131941-63-4 PTS*Val-Phe-OBzl 
• 93266-80-9 Trt-Val-Phe-OBzl 
• 5042-83-1 D-valine benzhydryl ester para-toluenesulfonate salt 
• 100841-28-9 N-Trityl-L-phenylalanyl-L-valinol 

Relevant academic research and scientific papers

Stabilized analogs of thymopentin. 1. 4,5-Ketomethylene pseudopeptides

The pentapeptide, thymopentin (Arg1-Lys2-Asp3-Val4-Tyr5) is known for its activity as an immunomodulating drug, but with limited half-life in plasma. In this first paper of a series of three studies, the synthesis of analogs stabilized at the peptide bond between the C-terminal amino acids via insertion of a ketomethylene moiety is described. N-Blocked pseudopeptides containing Val(k)Phe, Ala(k)Phe, and Val(k)Val units were prepared and attached to chloromethyl Merrifield resin via the carboxy terminal. Removal of the N-BOC group by trifluoroacetic acid was followed by sequential coupling with N-BOC dipeptides of aspartic acid to yield resin-bound N-BOC pseudotetrapeptides. Removal of N-BOC and coupling with N-BOC-r-N- tosylarginine followed by total cleavage of blocking groups and resin by HF afforded the target pseudopentapeptides. The analogs were found to compete favorably with thymopentin for binding to CEM cells, but binding was reduced by about 20-30% on average. All analogs showed significant enhancement of half-life versus thymopentin in mouse serum, but most showed only modest improvement in human serum. Insertion of proline or norleucine at position 2 in the chain caused a substantial increase in half-life (3-4-fold), while N- methylnorleucine conferred complete stability in the analogs.

Efficient Synthesis of N-Triphenylmethyl α-Amino Acids

A new one-pot synthesis of N-triphenylmethyl(trityl) α-amino acids 3 via their trityl ester 2 has been developed.

Efficient "One-Pot" Synthesis of N-Trityl Amino Acids

A sequential procedure has been developed whereby neutral amino acids 1 were tritylated via their corresponding trimethylsilyl esters 2 to afford, after mild hydrolysis, N-trityl amino acids 3 in high yields and purity.Hydroxy amino acids 4 were preferent