475264-72-3

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 57797-46-3 5-(2-mercapto-1,3-thiazol-4-yl)thiophene-2-carboxylic acid 
• 475264-57-4 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid 
• 475264-69-8 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}-N,N-dimethylthiophene-2-carboxamide 

Relevant academic research and scientific papers

New anti-MRSA and anti-VRE carbapenems: Synthesis and structure-activity relationships of 1β-metyl-2-(thiazol-2-ylthio)carbapenems

Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective. In order to find a new parenteral carbapenem antibiotic, which has potent antibacterial activity especially against methicillin-resistant staphylococci, vancomycin-resistant enterococci and penicillin-resistant Streptococcus pneumoniae, a series of 1β-methylcarbapenems with thiazol-2-ylthio groups at the C-2 position have been synthesized. Structure-activity relationships were investigated which led to SM-197436 (27), SM-232721 (44) and SM-232724 (41), being selected for further evaluation.