475272-20-9

Upstream product

• 475272-19-6 3-(3'-benzyl-4'-hydroxy-2-isobutyl-1,1'-biphenyl-4-yl)propanenitrile 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 475272-16-3 3-benzyl-4-methoxy-benzene-1-boronic acid 
• 434300-54-6 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate 
• 475272-18-5 3-(3'-benzyl-2-isobutyl-4'-methoxy-1,1'-biphenyl-4-yl)propanenitrile 
• 863508-40-1 (E)-3-(3-Isobutyl-4-methoxy-phenyl)-acrylonitrile 
• 475272-06-1 3-(4-hydroxy-3-isobutylphenyl)propanenitrile 
• 475272-05-0 3-(3-isobutyl-4-methoxyphenyl)propanenitrile 
• 475272-03-8 4-iodo-2-isobutylanisole 

Downstream Products

• 475094-55-4 3-(3'-Benzyl-4-(carboxymethoxy)-2,3-diisobutyl-1,1':4',1-terphenyl-4-yl)propanoic acid 
• 475272-23-2 3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile 
• 475272-35-6 3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile 
• 475272-22-1 3-(3',3-Dibenzyl-4-hydroxy-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile 
• 475272-34-5 3-(3'-benzyl-2,3''-4''-hydroxy-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile 
• 475272-21-0 3-(3',3-dibenzyl-2-isobutyl-4-methoxy-1,1':4',1-terphenyl-4-yl)propanenitrile 
• 475272-33-4 3-(3'-benzyl-2,3''-diisobutyl-4''-methoxy-1,1':4',1''-terphenyl-4-yl)propanenitrile 

Relevant academic research and scientific papers

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

(Chemical Equation Presented) HDM2 regulates p53 by binding to its transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic analysis of the HDM2/p53 complex revealed that three hydrophobic residues (F19, W23, L26) along one face of the p53 helical peptide are essential for binding (see picture). Terphenyl-based antagonists mimic the α-helical region of p53 and disrupt HDM2/p53 complexation.

Development of a potent Bcl-xL antagonist based on α-helix mimicry

The rational design of low-molecular weight ligands that disrupt protein-protein interactions is still a challenging goal in medicinal chemistry. Our approach to this problem involves the design of molecular scaffolds that mimic the surface functionality