475272-91-4Relevant academic research and scientific papers
Terphenyl-based Bak BH3 α-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL
Yin, Hang,Lee, Gui-In,Sedey, Kristine A.,Kutzki, Olaf,Park, Hyung Soon,Orner, Brendan P.,Ernst, Justin T.,Wang, Hong-Gang,Sebti, Said M.,Hamilton, Andrew D.
, p. 10191 - 10196 (2005)
We describe a general method for the mimicry of one face of an α-helix based on a terphenyl scaffold that spatially projects functionality in a manner similar to that of two turns of an α-helix. The synthetic scaffold reduces the flexibility and molecular
