4753-02-0 Usage
Uses
Used in Molecular Biology Research:
2'-Bromo-2'-deoxy-D-uridine is utilized as a cell proliferation marker for identifying and quantifying cells that are in the process of dividing. Its incorporation into the DNA of these cells enables researchers to study the rate and patterns of cell division in various biological contexts.
Used in Neuroscience:
In the field of neuroscience, 2'-Bromo-2'-deoxy-D-uridine is employed as a neurogenesis marker to trace the development and integration of new neurons in the brain. This application aids in understanding the mechanisms of learning, memory, and brain repair processes.
Used in Cancer Research:
2'-Bromo-2'-deoxy-D-uridine is used as a tool in oncology to investigate the growth dynamics of tumors and the metastatic spread of cancer cells. By monitoring the incorporation of BrdU into the DNA of cancer cells, researchers can gain insights into the aggressiveness of tumors and the effectiveness of potential therapeutic interventions.
Used in Drug Development:
In the pharmaceutical industry, 2'-Bromo-2'-deoxy-D-uridine serves as a compound in preclinical testing to assess the impact of new drugs on cell proliferation. This helps in determining the potential efficacy of drugs in controlling the growth of cancerous cells or modulating the regeneration of tissues.
Used in Diagnostics:
2'-Bromo-2'-deoxy-D-uridine is applied in diagnostic assays to detect and measure the rate of cell proliferation in various pathological conditions, including infections and autoimmune diseases, where an abnormal rate of cell division may be indicative of disease progression.
Each application of 2'-Bromo-2'-deoxy-D-uridine leverages its unique ability to be incorporated into DNA and subsequently detected, providing valuable insights into cellular processes across different scientific and medical disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 4753-02-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,5 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4753-02:
(6*4)+(5*7)+(4*5)+(3*3)+(2*0)+(1*2)=90
90 % 10 = 0
So 4753-02-0 is a valid CAS Registry Number.
4753-02-0Relevant academic research and scientific papers
Nucleic acid related compounds. 91. Biomimetic reactions are in harmony with loss of 2'-substituents as free radicals (not anions) during mechanism-based inactivation of ribonucleotide reductases. Differential interactions of azide, halogen, and alkylthio
Robins, Morris J.,Wnuk, Stanislaw F.,Hernández-Thirring, Amelia E.,Samano, Mirna C.
, p. 11341 - 11348 (2007/10/03)
The initial step in the mechanism-based inactivation of ribonucleotide reductases by 2'-chloro-2'deoxynucleotides is abstraction of H3' by a proximal free radical on the enzyme. The C3' radical is postulated to undergo spontaneous loss of chloride, and th
A Convenient Synthesis of 2'-Deoxyuridine
Bhat, K. S.,Rao, A. S.
, p. 678 - 679 (2007/10/02)
Reaction of uridine (2) with 2-acetoxybenzoyl bromide (10) furnishes 3',5'-di-O-acetyl-2'-bromo-2'-deoxyuridine (4).Reaction of 2 with 2-acetoxy-5-nitrobenzoyl chloride (11) furnishes 3',5'-di-O-acetyl-2'-chloro-2'-deoxyuridine (5).The transformation of 4 and 5 to 2'-deoxyuridine (1) is known .
