4753-04-2

Usage

Uses

Used in Pharmaceutical Research and Development:
2'-CHLORO-2'-DEOXYURIDINE is used as a research tool for the development of antiviral and antineoplastic drugs due to its ability to inhibit DNA synthesis and cause chain termination in replicating cells.
Used in Antiviral Applications:
In the field of virology, 2'-CHLORO-2'-DEOXYURIDINE is used as a potential treatment for various viral infections, leveraging its capacity to disrupt the normal function of infected cells.
Used in Anticancer Applications:
2'-CHLORO-2'-DEOXYURIDINE is used as a potential therapeutic agent in oncology for the treatment of cancers, capitalizing on its disruptive effects on DNA synthesis within cancer cells.
Used in Molecular Biology Research:
2'-CHLORO-2'-DEOXYURIDINE is used as a molecular probe for studying DNA replication and repair processes in cells, providing insights into cellular mechanisms and potential therapeutic targets.
Used in Preclinical Studies:
In preclinical research, 2'-CHLORO-2'-DEOXYURIDINE is utilized to evaluate its efficacy and safety in treating viral infections and cancers before moving to clinical trials.

Upstream product

• 10190-39-3 3',5'-Di-O-acetyl-2'-chloro-2'-deoxyuridine 
• 3736-77-4 2,2'-Anhydrouridine 
• 58-96-8 uridine 
• 34627-72-0 5'-O-acetyl-2'-chloro-2'-deoxyuridine 

Downstream Products

• 3736-77-4 2,2'-Anhydrouridine 
• 951-78-0 2'-deoxyuridine 
• 184296-92-2 Thiocarbonic acid O-[(2R,3R,4R,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester 

Relevant academic research and scientific papers

Method for preparing 2'-deoxyuridine

The invention discloses a method for preparing 2'-deoxyuridine shown in a preparation formula (IV) (please see the formula in the description). The method comprises the following steps that uridine shown in the formula (I) (please see the formula in the description) and a dehydrating agent are mixed in a solvent according to the following chemical equation, and uridine dehydrated matter shown in the formula (II) (please see the formula in the description) is generated under the catalyzing action of inorganic alkali; halogen hydride is added, and uridine halide shown in the formula (III) (please see the formula in the description) is generated through a halogenation reaction; hydrogen is introduced, and 2'-deoxyuridine shown in the formula (IV) is generated through a reduction reaction. According to the method for preparing 2'-deoxyuridine shown in the formula (IV), little harm is generated to the environment and the human body, and generated waste can be recycled; in addition, the one-pot preparation method is adopted, operation is easy, the labor cost is low, equipment investment is low, the production cycle is significantly shortened, and the method is suitable for industrialized mass production.

NOVEL ANTIVIRAL AND ANTITUMORAL COMPOUNDS

The present invention relates to novel phosphate-modified nucleosides, such as phosphoramidate nucleosides. The invention also relates to the use of these novel phosphate-modified nucleosides to treat or prevent viral infections and proliferative diseases

Facile synthesis of 2′-O-cyanoethyluridine by ring-opening reaction of 2,2′-anhydrouridine with cyanoethyl trimethylsilyl ether in the presence of BF3·Et2O

In this Letter, a facile method for the synthesis of 2′-O-cyanoethyluridine, which is a key intermediate in the synthesis of fully and partially 2′-O-cyanoethylated oligoribonucleotides as well as unmodified oligoribonucleotides, was developed by the ring

A packing-density metric for exploring the interior of folded RNA molecules

The intricate architectures of RNA molecules often contain expansive close-packed interfaces. The folding of the well-defined P4-P6 RNA domain was challenged by using a series of 2′-modified nucleotides with a narrow range of molecular volumes. The resulting folding interferences (see picture) reflect the spatial environment of the 2′-hydroxy groups and thereby define a packing-density metric.

Nucleic acid related compounds. 91. Biomimetic reactions are in harmony with loss of 2'-substituents as free radicals (not anions) during mechanism-based inactivation of ribonucleotide reductases. Differential interactions of azide, halogen, and alkylthio

The initial step in the mechanism-based inactivation of ribonucleotide reductases by 2'-chloro-2'deoxynucleotides is abstraction of H3' by a proximal free radical on the enzyme. The C3' radical is postulated to undergo spontaneous loss of chloride, and th

A Convenient Synthesis of 2'-Deoxyuridine

Reaction of uridine (2) with 2-acetoxybenzoyl bromide (10) furnishes 3',5'-di-O-acetyl-2'-bromo-2'-deoxyuridine (4).Reaction of 2 with 2-acetoxy-5-nitrobenzoyl chloride (11) furnishes 3',5'-di-O-acetyl-2'-chloro-2'-deoxyuridine (5).The transformation of 4 and 5 to 2'-deoxyuridine (1) is known .