475474-07-8Relevant academic research and scientific papers
N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.
Yang, Ginger X,Chang, Linda L,Truong, Quang,Doherty, George A,Magriotis, Plato A,de Laszlo, Stephen E,Li, Bing,MacCoss, Malcolm,Kidambi, Usha,Egger, Linda A,McCauley, Ermengilda,Van Riper, Gail,Mumford, Richard A,Schmidt, John A,Hagmann, William K
, p. 1497 - 1500 (2007/10/03)
Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N-tetrahydrofuroyl-(L)-phenylalanine derivative (17) and related analogues as potent VLA-4 antagonists with good oral bioavailability.
