475481-50-6

Downstream Products

• 103789-49-7 4-{2-[2-(4-Chloro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzonitrile 
• 1058703-17-5 2-(6-{2-[2-(4-chloro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-pyridin-3-ylmethyl)-tetrahydro-furan-2-carboxylic acid ethyl ester 
• 103789-59-9 4-{2-[2-(4-Chloro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzaldehyde 
• 103788-42-7 5-[1-(4-{2-[2-(4-Chloro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione 
• 876616-88-5 2-[5-methyl-2-(4-pyridin-3-yl-phenyl)-oxazol-4-yl]-ethanol 
• 1173794-33-6 C₃₇H₃₀Cl₂N₂O₅ 
• 1173794-78-9 C₃₁H₂₆Cl₂N₂O₅ 
• 521266-53-5 (2S)-1-({2-[2-(4-Chloro-phenyl)-5-methyl-oxazol-4-yl]-ethylamino}-acetyl)-pyrrolidine-2-carbonitrile 
• 956091-33-1 C₂₅H₂₆ClNO₄ 

Relevant academic research and scientific papers

OXAZOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. Formula I (I) or a pharmaceutically acceptable salt thereof, wherein: m is independenlly at each occurrence 1, 2, or 3, Z independently represents carbon (substituted with hydrogen or the optional substituents indicated herein) or nitrogen, provided that when Z is nitrogen then R6 is not attached to Z; R1 and R2 are independently -(C1-C7) alkyl(optionally substituted with one to three halogens), or R1 and R2 and the nitrogen to which they are attached form an azetidinyl ring, a pyrrolidinyl ring, or a piperidinyl ring, wherein further the azetidinyl, pyrrolidinyl, or piperidinyl ring so formed may be optionally substituted one to three times with R5; R6 is independently at each occurrence -H, -halogen, or -CH3.