475488-23-4 Usage
Uses
NVP-ADW742 is an IGF-1R inhibitor with IC50?of 0.17 μM.
Biological Activity
nvp-adw742 is a novel inhibitor of ifg-1receptor (igf-1r) kinase with the ic50 value of 0.17μm [1].nvp-adw742 has shown above 16-fold effective function against igf-1r than insulin receptor (insr). furthermore, nvp-adw742 has also been reported to inhibit other kinases , with the ic50 values of >10μm for her2, pdgfr, vegfr-2, or bcr-abl p210, and the ic50 values >5μm for c-kit [1]. besides, nvp-adw742 combined with etoposide and carboplatin has been reported to inhibit cell growth and induce cytotoxicity by mtt assay using the small cell lung cancer (sclc), including h526, h146, wba and h209 cell lines. in addition, nvp-adw742 has been revealed to completely inhibit the expression of vegf mrna which induced by igf-i in h526 cells [2].
references
[1] mitsiades cs1, mitsiades ns, mcmullan cj, poulaki v, shringarpure r, akiyama m, hideshima t, chauhan d, joseph m, libermann ta, garcía-echeverría c, pearson ma, hofmann f, anderson kc, kung al. inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors . cancer cell. 2004 mar; 5(3):221-30.[2]warshamana-greene gs1, litz j, buchdunger e, garcía-echeverría c, hofmann f, krystal gw. the insulin-like growth factor-i receptor kinase inhibitor, nvp-adw742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. clin cancer res. 2005 feb 15;11(4):1563-71.
Check Digit Verification of cas no
The CAS Registry Mumber 475488-23-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,5,4,8 and 8 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 475488-23:
(8*4)+(7*7)+(6*5)+(5*4)+(4*8)+(3*8)+(2*2)+(1*3)=194
194 % 10 = 4
So 475488-23-4 is a valid CAS Registry Number.
475488-23-4Relevant articles and documents
CANCER TREATMENT METHOD
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Page/Page column 47, (2008/06/13)
The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering an erb family inhibitor and an IGF-1R inhibitor to a mammal suffering from a cancer.