475597-75-2

Upstream product

• 475597-90-1 methyl 3-[N-(t-butoxycarbonyl)-3-(4-(5-phenylpentyloxy)phenyl)propylamino]propanoate 
• 847579-32-2 tert-butyl N-[3-(4-hydroxyphenyl)propyl]-β-alaninate 
• 847579-33-3 tert-butyl N-(tert-butoxycarbonyl)-N-[3-(4-hydroxyphenyl)propyl]-β-alaninate 
• 57400-89-2 4-(3-aminopropyl)phenol 
• 273939-77-8 methyl 3-[4-(5-phenylpentyloxy)phenyl]propanoate 
• 475597-80-9 3-[4-(5-phenylpentyloxy)phenyl]propanoyl chloride 
• 10521-91-2 5-phenylpentan-1-ol 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 

Relevant academic research and scientific papers

Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety

Structure-activity relationship of sphingosine-1-phosphate receptor agonist was examined. In terms of reducing the flexibility of molecule, hit compound 1 was modified to improve S1P1 agonistic activity as well as selectivity over S1P3 agonistic activity. Novel S1P agonists with cinnamyl scaffold or 1,2,5,6-tetrahydropyridine scaffold were identified.

CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined in the soecification.). Because of having an EDG-1 agonism, the compounds represented by formula (I) are useful in preventing and /or treating peripheral arterial disease such as arteriosclerosis obliterans, thromboangiitis obliterans, Buerger's disease or diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, stroke, myocardial infarction, edematous state, atherosclerosis, varicosity such as hemorrhoid, anal fissure or fistula ani, dissecting aneurysm of the aorta, angina, DIC, pleuritis, congestive heart failure, multiple organ failure, bedsore, burn, chronic ulcerative colitis, Crohn's disease, heart transplantation, renal transplantation, dermal graft, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, liver cirrhosis, chronic renal failure, or glomerular sclerosis.