475629-78-8Relevant academic research and scientific papers
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay
Kemnitzer, William,Jiang, Songchun,Zhang, Hong,Kasibhatla, Shailaja,Crogan-Grundy, Candace,Blais, Charles,Attardo, Giorgio,Denis, Real,Lamothe, Serge,Gourdeau, Henriette,Tseng, Ben,Drewe, John,Cai, Sui Xiong
scheme or table, p. 5571 - 5575 (2009/05/30)
As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as potential anticancer agents, we explored the removal of the chiral center at the 4-position and prepared a series of 4-aryl-2-oxo-2H-chromenes. It was f
Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
