475633-16-0Relevant academic research and scientific papers
Phosphonium lipocations as antiparasitic agents
Long, Timothy E.,Lu, Xiao,Galizzi, Melina,Docampo, Roberto,Gut, Jiri,Rosenthal, Philip J.
, p. 2976 - 2979 (2012)
Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi.
