475652-88-1

Basic information

• Product Name: 1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-3-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-1-one
• Synonyms: 1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-3-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-1-one
• CAS NO: 475652-88-1
• Molecular Weight: 421.459
• Mol File: 475652-88-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-3-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-3-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-1-one(475652-88-1)
• EPA Substance Registry System: 1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-3-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-1-one(475652-88-1)

Safety Data

• Hazardous Substances Data: 475652-88-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 54054-85-2 1-(3-nitrophenyl)piperazine 
• 33453-25-7 1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-ethanone 

Downstream Products

• 178928-38-6 3-[4-(3-acetylamino)-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-1H-pyrazolyl]-1-propanone 

Relevant articles and documents

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes.

A series of novel 3-substituted-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes in order to improve the in vitro and in vivo activity of our prototype 3-[4-(3-chlorophenyl)-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propene (2) were synthesized and evaluated by assays of growth inhibition against several tumor cell lines in vitro and antitumor activity against some tumor models when dosed both intraperitoneally and orally in vivo. Compounds 7a and 7e, the 3,5-difluorophenyl and 3,5-dichlorophenyl analogues of 2, respectively, showed significantly more potent cytotoxicity than 2 in vitro and potent antitumor activities without causing decrease of body temperature related to side effects.