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(6aS)-2-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinolin-1-ol is a complex organic compound with a molecular formula of C17H17NO3. It is a derivative of benzo[de][1,3]benzodioxolo[5,6-g]quinoline, featuring a 6aS stereochemistry, a methoxy group at the 2-position, and a methyl group at the 6-position. (6aS)-2-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinolin-1-ol is characterized by its tetrahydro structure, which means it has four hydrogen atoms added to the benzene ring, and a 4H-benzo[de][1,3]benzodioxolo[5,6-g]quinolin-1-ol core. The presence of the benzodioxole ring and the quinoline nucleus suggests potential applications in medicinal chemistry, particularly as a precursor or intermediate in the synthesis of pharmaceuticals or other bioactive molecules. The specific arrangement of functional groups and the stereochemistry at the 6a position may influence its reactivity, physical properties, and potential biological activity.

476-71-1

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476-71-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 476-71-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 476-71:
(5*4)+(4*7)+(3*6)+(2*7)+(1*1)=81
81 % 10 = 1
So 476-71-1 is a valid CAS Registry Number.

476-71-1Relevant academic research and scientific papers

Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: An SAR study

Ponnala, Shashikanth,Chaudhary, Sandeep,Gonzalez-Sarrias, Antonio,Seeram, Navindra P.,Harding, Wayne W.

, p. 4462 - 4464 (2011)

A series of synthetic aporphine derivatives structurally related to domesticine and nantenine (ring A, N6 and ring C truncated analogs), was evaluated in MTS cytotoxicity assays against the human colon cancer cell lines, HCT-116 and Caco-2. In general, the C1 position of ring A is tolerant of alkoxy substituents as well as a benzoyl ester functionality. Other modifications evaluated resulted in a decrease in cytotoxic activity. The most potent compounds identified had IC50 values in the range 23-38 μM, comparable to the known cytotoxic agent, etoposide.

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