476155-39-2

Upstream product

• 476155-38-1 ethyl 3-methyl-5-(4-trifluoromethylphenyl)thiophene-2-carboxylate 
• 476155-77-8 3-methyl-5-(4-trifluoromethyl-phenyl)-thiophene-2-carbaldehyde 
• 128796-39-4 4-trifluoromethylphenylboronic acid 

Downstream Products

• 918164-58-6 2-chloromethyl-3-methyl-5-(4-trifluoromethylphenyl)thiophene 
• 908250-72-6 1-(4-hydroxy-3-methylphenyl)-3-[3-methyl-5-(4-trifluoromethylphenyl)thiophen-2-yl]propan-1-one 

Relevant academic research and scientific papers

HETEROCYCLIC GPR40 MODULATORS

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndr

Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/ dibromothiazoles and arylboronic acids. Synthesis of PPARβ/δ agonists

A reactivity study, aided by NMR spectroscopy, allowed a mechanistic rationale to be postulated for the palladium-catalyzed regioselective coupling of arylboronic acid (and arylstannane where feasible) at the position next to the sulfur atom in functional

THIOPHENE DERIVATIVE PPAR MODULATORS

The present invention is directed to compounds represented by the following structural formula, Formula I: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) X is selected from the group consisting of O, S, S(O)2, N, and a bond; (b) U is an aliphatic linker wherein one carbon atom of the aliphatic linker may be replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with R30; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; and (d) E is C(R3)(R4)A or A.