476183-15-0Relevant academic research and scientific papers
MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1′ amides
Fobian, Yvette M.,Freskos, John N.,Barta, Thomas E.,Bedell, Louis J.,Heintz, Robert,Kassab, Darren J.,Kiefer, James R.,Mischke, Brent V.,Molyneaux, John M.,Mullins, Patrick,Munie, Grace E.,Becker, Daniel P.
scheme or table, p. 2823 - 2825 (2011/06/24)
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1′ substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.
