476310-40-4Relevant academic research and scientific papers
A new access to polyhydroxy piperidines of the azasugar class: Synthesis and glycosidase inhibition studies
Pandey, Ganesh,Kapur, Manmohan,Islam Khan,Gaikwad, Sushama M.
, p. 3321 - 3326 (2007/10/03)
A new synthetic strategy has been devised to access a variety of polyhydroxylated piperidines belonging to the azasugar class of glycosidase inhibitors. The key precursor (3aR, 7aR)-5-benzyl-2,2-dimethyl-7-methylenehexahydro[1,3]dioxo[4,5-c]pyridine is obtained by photoinduced electron transfer (PET) cyclization of the corresponding α-trimethylsilylmethylamine radical cation to the tethered acetylene functionality. The new molecules have been evaluated for inhibitory properties for certain β-glycosidases and have been found to be moderate to weak inhibitors of the enzymes under study.
Design and Development of a Common Synthetic Strategy for a Variety of 1-N-Iminosugars
Pandey, Ganesh,Kapur, Manmohan
, p. 3883 - 3886 (2007/10/03)
(Matrix Presented) A new synthetic strategy has been developed for a general approach toward the synthesis of a variety of 1-N-iminosugar-type glycosidase inhibitors utilizing precursors developed by the PET-mediated cyclization of α-trimethylsilylmethyla
