476313-99-2

Basic information

• Product Name: 2-Ethoxymethyl-4-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one
• Synonyms: 2-Ethoxymethyl-4-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one
• CAS NO: 476313-99-2
• Molecular Weight: 361.397
• Mol File: 476313-99-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Ethoxymethyl-4-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxymethyl-4-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one(476313-99-2)
• EPA Substance Registry System: 2-Ethoxymethyl-4-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one(476313-99-2)

Safety Data

• Hazardous Substances Data: 476313-99-2(Hazardous Substances Data)

Upstream product

• 476313-98-1 4-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-2H-isoxazol-5-one 
• 503071-67-8 2-(4-fluorophenyl)-3-oxo-3-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid methyl ester 
• 503071-70-3 2-(4-fluorophenyl)-3-hydroxy-3-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid methyl ester 
• 1074-68-6 4-formyl-2-(methylthio)pyrimidine 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 3188-13-4 ethyl chloromethyl ether 

Relevant articles and documents

The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production

4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-α) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-α production.