476314-27-9Relevant academic research and scientific papers
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production
Laughlin, Steven K.,Clark, Michael P.,Djung, Jane F.,Golebiowski, Adam,Brugel, Todd A.,Sabat, Mark,Bookland, Roger G.,Laufersweiler, Matthew J.,VanRens, John C.,Townes, Jennifer A.,De, Biswanath,Hsieh, Lily C.,Xu, Susan C.,Walter, Richard L.,Mekel, Marlene J.,Janusz, Michael J.
, p. 2399 - 2403 (2007/10/03)
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-α) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-α production.
Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
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, (2008/06/13)
Isoxazolone compounds having the generic structure: are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, Crohn's disease, ulcerative colitis,
