476360-70-0

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 75305-81-6 4-isobutyryloxyacetophenone 
• 82410-32-0 ganciclovir 
• 476360-57-3 4-isobutyryloxyphenacyl bromide 

Downstream Products

• 929258-19-5 C₅₅H₇₃N₇O₁₁S₂ 
• 929258-13-9 3-(2,2-dimethyl-[1,3]dioxan-5-yloxymethyl)-6-(4-hydroxy-phenyl)-8-oxo-3,8-dihydro-1,3,4,5,7a-pentaaza-s-indacene-5-carboxylic acid tert-butyl ester 
• 929258-15-1 3-(2,2-dimethyl-[1,3]dioxan-5-yloxymethyl)-6-(4-hydroxy-phenyl)-3,5-dihydro-1,3,4,5,7a-pentaaza-s-indacen-8-one 

Relevant academic research and scientific papers

Synthesis of a technetium-99m labeled tricyclic ganciclovir analog for non-invasive reporter gene expression imaging

A potential radiopharmaceutical and HSV1-TK substrate, 3-((1,3-dihydroxypropan-2-yloxy)-methyl)-6-(4-(3-((2-mercaptoethyl)(2-(2-mercaptoethyl-amino)-ethyl)amino)propoxy)phenyl)-3H-imidazopurin-9(5H)-one-oxo-technetium(V), was synthesized via a converging

Synthesis and fluorescent properties of 6-(4-biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine analogues of acyclovir and ganciclovir

Tricyclic (T) analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2) carrying the 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine system [i.e., 6-(4-BrPh)TACV, 5 and 6-(4-BrPh)TGCV, 6] were transformed into 6-[(4′-R2)-4-biphenylyl] derivatives of T

Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir

In search of strongly fluorescent tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2), derivatives of the 3,9-dihydro-9-oxo-5H-imidazo[1,2-α]purine system, several 6-[4- (acyloxy)-phenyl], 6-[4-(acylamino)phenyl], and 6-[4-(phenoxycarbonyloxy)phenyl]-substituted TACV and TGCV analogues were synthesized and evaluated for their activity against herpes simplex virus types 1 and 2 in cell culture. All TACV and TGCV analogues showed strong fluorescence (quantum yield of 30-65% vs 2-aminopurine 100%). The 6-[4-(phenoxycarbonyloxy)phenyl]-substituted compounds 11 and 19 displayed the best combination of the fluorescence and antiviral potency.