476364-25-7Relevant academic research and scientific papers
Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
Achermann, Guido,Ballard, Theresa M.,Blasco, Francesca,Broutin, Pierre-Emmanuel,Buettelmann, Bernd,Fischer, Holger,Graf, Martin,Hernandez, Maria-Clemencia,Hilty, Peter,Knoflach, Frederic,Koblet, Andreas,Knust, Henner,Kurt, Anke,Martin, James R.,Masciadri, Raffaello,Porter, Richard H.P.,Stadler, Heinz,Thomas, Andrew W.,Trube, Gerhard,Wichmann, Juergen
scheme or table, p. 5746 - 5752 (2010/04/30)
Through iterative design cycles we have discovered a number of novel new classes where the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine was deemed the most promising GABAA α5 inverse agonist class with potential for cognitive enhanc
Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
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, (2008/06/13)
The present invention is a compound of formula wherein R1 is halogen or lower alkyl; R2 is hydrogen, lower alkyl, cycloalkyl, —(CH2)m-phenyl, wherein the phenyl ring may be substituted by lower alkoxy, or is —(CH2)m-indolyl; R3 is —C(O)O-lower alkyl, —C(O)OH, or a five membered heteroaromatic group, which rings may be substituted by lower alkyl or cycloalkyl; n is 0, 1 or 2; m is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof. Compound I shows high affinity and selectivity for GALA A α5 receptor binding sites.
