476371-68-3

Usage

Chemical Class

The compound belongs to the pyrazolopyrimidine class.

Molecular Weight

The molecular weight of the compound is 199.24 g/mol.

Biological Activity

PI-103 is a phosphoinositide 3-kinase (PI3K) inhibitor.

Potential Use

PI-103 has potential as a drug candidate for cancer treatment.

Mechanism of Action

PI-103 inhibits the growth and proliferation of cancer cells by blocking the PI3K pathway, which is often dysregulated in cancer.

Efficacy

PI-103 has shown potential in inhibiting the growth of tumor cells and inducing apoptosis, making it a promising target for further research and drug development.

Upstream product

• 77287-34-4 formamide 
• 476371-64-9 5-amino-3-isopropyl-1H-pyrazole-4-carbonitrile 
• 2380-63-4 4-Aminopyrazolo<3,4-d>pyrimidin 
• 151266-23-8 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine 
• 476371-59-2 2-(2-methylpropanoyl)propanedinitrile 
• 54122-57-5 2-(1-Methoxy-2-methylpropylidene)malononitrile 

Downstream Products

• 476371-70-7 (2R,3R,4R,5R)-2-(4-amino-3-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5-[(benzoyloxy)methyl]tetrahydrofuran-3,4-diyl dibenzoate 

Relevant academic research and scientific papers

ATG7 INHIBITORS AND THE USES THEREOF

Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

Inhibitor scaffolds as new allele specific kinase substrates

The elucidation of protein kinase signaling networks is challenging due to the large size of the protein kinase superfamily (>500 human kinases). Here we describe a new class of orthogonal triphosphate substrate analogues for the direct labeling of analog