476452-69-4

Upstream product

• 476453-09-5 C₄₁H₅₈O₇ 
• 476452-71-8 (1S,2R)-2-Methyl-1-[(2R,3R)-3-((R)-1-methyl-butyl)-oxiranyl]-pent-4-yn-1-ol 
• 476452-72-9 C₂₁H₂₈O₄ 
• 476452-84-3 (2E,4E)-7-((2R,3R)-3-{1-[(2R,3R)-3-allyl-1,4-dioxaspiro[4.4]non-2-yl]vinyl}-1,4-dioxaspiro[4.4]non-2-yl)-3-methylocta-2,4,7-trienoic acid 
• 476452-86-5 (1R)-3-O-[(2E,4E)-7-((2R,3R)-3-{1-[(2R,3R)-3-allyl-1,4-dioxaspiro[4.4]non-2-yl]vinyl}-1,4-dioxaspiro[4.4]non-2-yl)-3-methylocta-2,4,7-trienoyl]-1,2-anhydro-4,5-dideoxy-1-[(1R)-1-methylbutyl]-4-prop-2-yn-1-yl-L-arabinitol 
• 476453-07-3 (2S,3R)-3-[1-((2R,3R)-3-Allyl-1,4-dioxa-spiro[4.4]non-2-yl)-vinyl]-1,4-dioxa-spiro[4.4]nonane-2-carbaldehyde 
• 476453-06-2 {(2R,3R)-3-[1-((2R,3R)-3-Allyl-1,4-dioxa-spiro[4.4]non-2-yl)-vinyl]-1,4-dioxa-spiro[4.4]non-2-yl}-methanol 
• 476453-08-4 9H-fluoren-9-ylmethyl (2E,4E)-7-((2R,3R)-3-{1-[(2R,3R)-3-allyl-1,4-dioxaspiro[4.4]non-2-yl]vinyl}-1,4-dioxaspiro[4.4]non-2-yl)-3-methylocta-2,4,7-trienoate 
• 476453-04-0 Trifluoro-methanesulfonic acid (2R,3R)-3-{1-[(2R,3R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-1,4-dioxa-spiro[4.4]non-2-yl]-vinyl}-1,4-dioxa-spiro[4.4]non-2-ylmethyl ester 
• 476453-03-9 ((2R,3R)-3-{1-[(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1,4-dioxa-spiro[4.4]non-2-yl]-vinyl}-1,4-dioxa-spiro[4.4]non-2-yl)-methanol 
• 476452-83-2 ((2R,3R)-3-{1-[(2R,3R)-3-prop-2-yn-1-yl-1,4-dioxaspiro[4.4]non-2-yl]vinyl}-1,4-dioxaspiro[4.4]non-2-yl)methanol 
• 476452-79-6 tert-Butyl-{(E)-4-(4-methoxy-benzyloxy)-1-[(E)-3-(4-methoxy-benzyloxy)-propenyl]-but-2-enyloxy}-dimethyl-silane 
• 476452-82-1 {(2R,3R)-3-[1-((2R,3R)-3-Hydroxymethyl-1,4-dioxa-spiro[4.4]non-2-yl)-vinyl]-1,4-dioxa-spiro[4.4]non-2-yl}-methanol 
• 476452-92-3 1-[(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-6-trimethylsilanyl-hex-5-ynyloxymethyl]-4-methoxy-benzene 

Relevant academic research and scientific papers

Ruthenium-catalyzed alkene-alkyne coupling: Synthesis of the proposed structure of amphidinolide A

The ruthenium-catalyzed alkene-alkyne coupling provides a powerful method for the synthesis of 1,4 dienes and a way to simplify synthetic strategy. The latter potential is explored in the context of a synthesis of the assigned structure of amphidinolide A

Total synthesis of (+)-amphidinolide A. Structure elucidation and completion of the synthesis

The structure elucidation of (+)-amphidinolide A, a cytotoxic macrolide, has been accomplished by employing a combination of NMR chemical shift analysis and total synthesis. The 20-membered ring of amphidinolide A was formed by a ruthenium-catalyzed alken